BMS-903452

BMS-903452 is a potent and selective GPR119 agonist for diabetes research[1].

Product Specifications

CAS Number

[1339944-47-6]

UNSPSC

12352005

Target

GPR119

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bms-903452.html

Solubility

10 mM in DMSO

Smiles

ClC1=CN=C(N2CCC(OC3=CC(N(C4=CC=C(S(=O)(C)=O)C=C4F)C=C3Cl)=O)CC2)N=C1

Molecular Formula

C21H19Cl2FN4O4S

Molecular Weight

513.37

References & Citations

[1]Wacker DA, et al. Discovery of 5-chloro-4- ((1- (5-chloropyrimidin-2-yl) piperidin-4-yl) oxy) -1- (2-fluoro-4- (methylsulfonyl) phenyl) pyridin-2 (1H) -one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J Med Chem. 2014 Sep 25;57 (18) :7499-508.