CGS-12066 (maleate)

CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[1350965-83-1]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgs-12066-maleate.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(CC1)C2=NC3=C(C=CC(C(F)(F)F)=C3)N4C2=CC=C4.O=C(/C=C\C(O)=O)O

Molecular Formula

C21H21F3N4O4

Molecular Weight

450.41

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Schoeffter P, et al. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?. Naunyn Schmiedebergs Arch Pharmacol. 1989;339 (6) :675-683.