DBCO-Sulfo-NHS ester (sodium)

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[1400191-52-7]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

Dye Reagents

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-sulfo-nhs-ester-sodium.html

Purity

97.98

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O

Molecular Formula

C25H21N2NaO8S

Molecular Weight

532.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung S, et al. Facile strategy for protein conjugation with chitosan-poly (ethylene glycol) hybrid microparticleplatforms via strain-promoted alkyne-azide cycloaddition (SPAAC) reaction. Biomacromolecules. 2013 Nov 11;14 (11) :3892-902.