Pyrene-amido-PEG4-azide

Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Pyrene-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1817735-36-6]

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyrene-amido-peg4-azide.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C2C3=C1C=CC4=C3C(CC=C4)=CC2)NCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C25H28N4O4

Molecular Weight

448.51

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562