DHQZ 36
DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages with an EC50 of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].
Product Specifications
CAS Number
1542098-94-1
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhqz-36.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=CC=C(F)C=C2)C(C3=CC=C(CC)S3)NC4=C1C=C(F)C=C4
Molecular Formula
C21H18F2N2OS
Molecular Weight
384.44
References & Citations
[1]Craig E, et al. Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections. PLoS Negl Trop Dis. 2017 May 15;11 (5) :e0005556.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
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