ONO-3403

ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors[1][2][3][4].

Product Specifications

CAS Number

[181586-07-2]

UNSPSC

12352005

Target

Apoptosis; Ser/Thr Protease

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ono-3403.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)/C=C(C(N(CC=C)CC(OCC)=O)=O)\C)OC2=CC=C(C=C2)C(N)=N.CS(=O)(O)=O

Molecular Formula

C26H31N3O8S

Molecular Weight

545.60

References & Citations

[1]Tumurkhuu G, et al. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011;17 (1) :97-105.|[2]Hiwasa T, et al. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998;126 (2) :221-225.|[3]Ohkoshi M, et al. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002;22 (2A) :821-823.