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Kentsin

Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility[1][3][5][6].

Product Specifications

CAS Number

[56767-30-7]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kentsin.html

Solubility

10 mM in DMSO

Smiles

NCCCC[C@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](N)[C@@H](C)O)=O)=O)CCCNC(N)=N)=O)C(O)=O

Molecular Formula

C21H40N8O6

Molecular Weight

500.59

References & Citations

[1]Fox DA, et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8 (4) :613-8. |[2]Suk WA, et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52 (Pt 1) :189-94. |[3]Bueno L, et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114 (1) :67-70. |[4]Buéno L, et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39 (2) :141-6. |[5]Wieczorek Z, et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15 (2) :215-21.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-123492/Kentsin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-123492/

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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