H1PVAT

H1PVAT is a potent and selective inhibitor of poliovirus serotypes (PV-1, PV-2, PV-3), and inhibits early stage of the replication. H1PVAT interacts with viral capsid directly and protects PV against heat inactivation[1][2].

Product Specifications

CAS Number

[351438-49-8]

UNSPSC

12352005

Target

Enterovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/h1pvat.html

Purity

96.40

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=NN2C(C(F)(F)F)CC(C3=CC=CS3)NC2=C1)NC4=CC=C(C#N)C=C4

Molecular Formula

C19H14F3N5OS

Molecular Weight

417.42

References & Citations

[1]Tijsma A, et al. H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1. Antiviral Res. 2014 Oct;110:1-9.|[2]Tijsma A. Antiviral strategies against polio and other enteroviruses. 2018.