SKF1
SKF1 is a FK506 suppressor, causes a mitochondrially induced death in low salt, concomitant with the release of reactive oxygen species (ROS) [1].
Product Specifications
CAS Number
[678997-25-6]
UNSPSC
12352005
Hazard Statement
H318
Target
FKBP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/skf1.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1CCCCC1)C2=CC=C(C(NCCCCCCCC)=N)C=C2.[H]Cl
Molecular Formula
C23H37ClN2O2
Molecular Weight
409.01
Precautions
P280-P305+P351+P338
References & Citations
[1]Rebecca A Butcher, et al. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Chem Biol. 2003 Jun;10 (6) :521-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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