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SKF1

SKF1 is a FK506 suppressor, causes a mitochondrially induced death in low salt, concomitant with the release of reactive oxygen species (ROS) [1].

Product Specifications

CAS Number

[678997-25-6]

UNSPSC

12352005

Hazard Statement

H318

Target

FKBP; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/skf1.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC1CCCCC1)C2=CC=C(C(NCCCCCCCC)=N)C=C2.[H]Cl

Molecular Formula

C23H37ClN2O2

Molecular Weight

409.01

Precautions

P280-P305+P351+P338

References & Citations

[1]Rebecca A Butcher, et al. A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae. Chem Biol. 2003 Jun;10 (6) :521-31.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-123454/SKF1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-123454/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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