Transcainide
Transcainide (R 54718) is an orally active antiarrhythmic agent. Transcainide blocks voltage-sensitive sodium channels activated by poison dart frog toxin[1][2].
Product Specifications
CAS Number
[88296-62-2]
Product Name Alternative
R 54718
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/transcainide.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C=CC=C1C)C)C2(CCN(CC2)[C@H]3[C@@H](CCCC3)O)N(C)C
Molecular Formula
C22H35N3O2
Molecular Weight
373.53
References & Citations
[1]R Stroobandt, Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718) . Eur J Clin Pharmacol. 1987;32 (5) :449-56.|[2]Zamponi GW, et al. Transcainide causes two modes of open-channel block with different voltage sensitivities in batrachotoxin-activated sodium channels. Biophys J. 1994 Sep;67 (3) :1028-39. doi: 10.1016/S0006-3495 (94) 80568-5. Erratum in: Biophys J 1995 Mar;68 (3) :1197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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