Transcainide

Transcainide (R 54718) is an orally active antiarrhythmic agent. Transcainide blocks voltage-sensitive sodium channels activated by poison dart frog toxin[1][2].

Product Specifications

CAS Number

[88296-62-2]

Product Name Alternative

R 54718

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/transcainide.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C=CC=C1C)C)C2(CCN(CC2)[C@H]3[C@@H](CCCC3)O)N(C)C

Molecular Formula

C22H35N3O2

Molecular Weight

373.53

References & Citations

[1]R Stroobandt, Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718) . Eur J Clin Pharmacol. 1987;32 (5) :449-56.|[2]Zamponi GW, et al. Transcainide causes two modes of open-channel block with different voltage sensitivities in batrachotoxin-activated sodium channels. Biophys J. 1994 Sep;67 (3) :1028-39. doi: 10.1016/S0006-3495 (94) 80568-5. Erratum in: Biophys J 1995 Mar;68 (3) :1197.