CPI-4203
CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG) . CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].
Product Specifications
CAS Number
[1628214-07-2]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpi-4203.html
Purity
99.0
Solubility
DMSO : 25 mg/mL (ultrasonic; warming)
Smiles
N#CC1=C(N2N=C1)NC(C3=C(C=CC=C3)C)=C(C2=O)CC
Molecular Formula
C16H14N4O
Molecular Weight
278.31
References & Citations
[1]Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12 (7) :531-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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