DDRI-18
DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent[1].
Product Specifications
CAS Number
4402-18-0
UNSPSC
12352005
Hazard Statement
H315-H319-H335-H413
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ddri-18.html
Solubility
10 mM in DMSO
Smiles
NC1=CC=CC(C2=NC3=CC=C(C=C3N2)C4=CC=C5N=C(NC5=C4)C6=CC(N)=CC=C6)=C1
Molecular Formula
C26H20N6
Molecular Weight
416.48
Precautions
P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]D W Jun, et al. Characterization of DDRI-18 (3,3'- (1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl) dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol. 2012 Sep;167 (1) :141-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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