DDRI-18

DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent[1].

Product Specifications

CAS Number

[4402-18-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H335-H413

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ddri-18.html

Solubility

10 mM in DMSO

Smiles

NC1=CC=CC(C2=NC3=CC=C(C=C3N2)C4=CC=C5N=C(NC5=C4)C6=CC(N)=CC=C6)=C1

Molecular Formula

C26H20N6

Molecular Weight

416.48

Precautions

P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]D W Jun, et al. Characterization of DDRI-18 (3,3'- (1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl) dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol. 2012 Sep;167 (1) :141-50.