5α-Hydroxy-6-keto cholesterol
5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].
Product Specifications
CAS Number
[13027-33-3]
UNSPSC
12352211
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/5α-hydroxy-6-keto-cholesterol.html
Purity
99.9
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](CC([C@]1(C[C@H](CC2)O)O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
Molecular Formula
C27H46O3
Molecular Weight
418.65
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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DDR1 (NEP, Cell Adhesion Kinase, CD167, CD167a Antigen, EDDR1, ENTRK4, Mammary carcinoma Kinase 10, PTK3, PTK3A, RTK6, Tyrosine-Protein Kinase CAK, CAK, DDR, Discoidin domain Receptor 1, HGK2, MCK-10, NTRK4, Protein-Tyrosine Kinase 3A, Protein-Tyrosine Kinase RTK-6, TRK E, TRKE, Tyrosine Kinase DDR)