CRT 0105446
CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM[1].
Product Specifications
CAS Number
[1661846-05-4]
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crt-0105446.html
Solubility
10 mM in DMSO
Smiles
CC(C(NC1=NC=C(S1)C2=C(C=NC=C2)C3=CC=C(C=C3C(F)(F)F)OC)=O)C
Molecular Formula
C20H18F3N3O2S
Molecular Weight
421.44
References & Citations
[1]Mark D Charles, et al. Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem. 2015 Oct 22;58 (20) :8309-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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