Trk-IN-1
Trk-IN-1 (example 9), a potent tropomyosin-related kinase (Trk) inhibitor, shows potency against TrkA (3.7 nM) and TrkB (94 nM), respectively[1].
Product Specifications
CAS Number
1402438-37-2
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trk-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=CC(NC(CC2=CC=C(C=C2)C(F)(F)F)=O)=C1)C3=CN([C@@H](C)CO)C4=NC=NC=C34
Molecular Formula
C24H20F3N5O3
Molecular Weight
483.44
References & Citations
[1]Mark David Andrews, et al. Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases. WO2012137089A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB
Frequently Asked Questions
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