Mefruside

Mefruside is an orally active diuretic and a carbonic anhydrase inhibitor, with a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension[1][2].

Product Specifications

CAS Number

[7195-27-9]

UNSPSC

12352005

Hazard Statement

H315-H319-H335-H373

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mefruside.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)(N(CC2(OCCC2)C)C)=O

Molecular Formula

C13H19ClN2O5S2

Molecular Weight

382.88

Precautions

P260-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Häussinger D, et al. Liver carbonic anhydrase and urea synthesis. Hepatology. 1988 Mar-Apr;8 (2) :435. |[2]Brogden RN, et al. Mefruside: a preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension. Drugs. 1974;7 (6) :419-25.