XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM) [1].
Product Specifications
CAS Number
346689-77-8
Product Name Alternative
MLN576
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xr11576.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1
Molecular Formula
C23H24N4O2
Molecular Weight
388.46
References & Citations
[1]Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15 (9) :849-60.|[2]Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13 (1) :15-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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