K00135
K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets[1].
Product Specifications
CAS Number
869650-21-5
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k00135.html
Purity
98.03
Solubility
DMSO : 11.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
Molecular Formula
C18H18N4O
Molecular Weight
306.36
References & Citations
[1]Pogacic V, et al. Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer research, 2007, 67 (14) : 6916-6924.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Retinoic Acid Receptor alpha (RARA) Mouse Monoclonal Antibody [Clone ID: OTI7B9]](https://cdn.genprice.uk/products/937/68dd18b9061270361e907ed1/imageurl/cf806341.webp)
CF806341 100 µg
Retinoic Acid Receptor alpha (RARA) Mouse Monoclonal Antibody [Clone ID: OTI7B9]
Sign In for Pricing
View Details ![Anti-FAM38A/PIEZO1 Antibody [2-10]](https://cdn.genprice.uk/products/992/68dd1c90061270361ea827b7/imageurl01/m1005-2tr.webp)
BNC942290-100 1x 100 µL
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) (CFTR/2290R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![FRS2 Recombinant Rabbit Monoclonal Antibody [JE30-77]](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea825f8/imageurl/ha721434.webp)
HA721434 100 µL
FRS2 Recombinant Rabbit Monoclonal Antibody [JE30-77]
Sign In for Pricing
View Details