K00135
K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets[1].
Product Specifications
CAS Number
869650-21-5
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k00135.html
Purity
98.03
Solubility
DMSO : 11.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
Molecular Formula
C18H18N4O
Molecular Weight
306.36
References & Citations
[1]Pogacic V, et al. Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer research, 2007, 67 (14) : 6916-6924.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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