(Rac) -SAR131675
(Rac) -SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM[1][2].
Product Specifications
CAS Number
1092539-44-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-sar131675.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N)N(CC)C2=C(C=CC(C#CC(C)(O)COC)=N2)C1=O)NC
Molecular Formula
C18H22N4O4
Molecular Weight
358.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Mitroshina EV, et al. Neuroprotective Effect of Kinase Inhibition in Ischemic Factor Modeling In Vitro. Int J Mol Sci. 2021;22 (4) :1885.|[2]Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11 (8) :1637-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR3/Flt-4
Available Sizes
Frequently Asked Questions
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