CP-532623
CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3].
Product Specifications
CAS Number
[261947-38-0]
UNSPSC
12352005
Hazard Statement
H302
Target
CETP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cp-532623.html
Purity
99.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(N1[C@H](CC)C[C@H](N(C(C)=O)CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=C1C=CC(C(F)(F)F)=C3)OC(C)C
Molecular Formula
C27H27F9N2O3
Molecular Weight
598.50
Precautions
H302
References & Citations
[1]Blasi E, et al. Effects of CP-532,623 and torcetrapib, cholesteryl ester transfer protein inhibitors, on arterial blood pressure. J Cardiovasc Pharmacol. 2009 Jun;53 (6) :507-16.|[2]Trevaskis NL, et al. The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles. Pharm Res. 2010 Sep;27 (9) :1949-64.|[3]Trevaskis NL, et al. The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623) . Pharm Res. 2010 May;27 (5) :878-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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