Lubabegron (fumarate)

Lubabegron fumarate is a potent modulator of β-adrenergic receptor (β-AR) . Lubabegron fumarate demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron fumarate reduces NH3 gas emissions from an animal or its waste. Lubabegron fumarate is available as an animal supplement[1][2].

Product Specifications

CAS Number

[391926-19-5]

Product Name Alternative

LY-591281; LY-488756 (fumarate)

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/lubabegron-fumarate.html

Solubility

10 mM in DMSO

Smiles

OC(/C=C/C(O)=O)=O.N#CC1=C(N=CC=C1)OC2=CC=C(C=C2)CC(NC[C@H](O)COC3=C(C4=CC=CS4)C=CC=C3)(C)C

Molecular Formula

C29H29N3O3S.1/2C4H4O4

Molecular Weight

557.19

References & Citations

[1]Hwang JH, et al. Lubabegron fumarate acts as a β-adrenergic receptor antagonist in cultured bovine intramuscular and subcutaneous adipocytes. J Anim Sci. 2022 Mar 1;100 (3) :skac052.|[2]Corona A K, et al. The Impact of Lubabegron Supplementation on Meat Quality of Feedlot Steers. Meat and Muscle Biology, 2025, 9 (1) .