Henagliflozin
Henagliflozin (SHR3824) is a potent selective sodium-glucose co-transporter 2 (SGLT2) inhibitor with the IC50 values of 2.38 and 4324 nM for human SGLT2 and SGLT1, respectively. Henagliflozin can be used in diabetes research[1].
Product Specifications
CAS Number
1623804-44-3
Product Name Alternative
SHR3824
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/henagliflozin.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@]2(C3=CC(CC4=CC(F)=C(C=C4)OCC)=C(C=C3)Cl)O[C@](CO2)([C@H]([C@@H]1O)O)CO
Molecular Formula
C22H24ClFO7
Molecular Weight
454.87
References & Citations
[1]Pang-ke Yan, et al. SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models. Acta Pharmacol Sin. 2014 May;35 (5) :613-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
SGLT2
Available Sizes
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