Aristolactam BIII
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
Product Specifications
CAS Number
53948-10-0
UNSPSC
12352005
Target
DYRK
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aristolactam-biii.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C3C1=CC(OC)=C(OC)C3=C4C(C=CC(OC)=C4)=C2
Molecular Formula
C18H15NO4
Molecular Weight
309.32
References & Citations
[1]Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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