Danshenol B

Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC50 value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy[1].

Product Specifications

CAS Number

[189308-09-6]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/danshenol-b.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@](CC(C)=O)(O)C2=C(C3=C1[C@@H](C)CO3)C=CC4=C2CCCC4(C)C

Molecular Formula

C22H26O4

Molecular Weight

354.44

References & Citations

[1]Tezuka Y, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo) . 1997 Aug;45 (8) :1306-11.