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PKCiota-IN-2

PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively[1].

Product Specifications

CAS Number

2230055-52-2

UNSPSC

12352005

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pkciota-in-2.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=C(CNCC2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3

Molecular Formula

C24H21N5O

Molecular Weight

395.46

References & Citations

[1]Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61 (10) :4386-4396.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKCα; PKCε; PKCι

Frequently Asked Questions

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