PKCiota-IN-1
PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].
Product Specifications
CAS Number
2230052-97-6
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkciota-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(CNC(CF)C2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3
Molecular Formula
C25H22FN5O
Molecular Weight
427.47
References & Citations
[1]Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61 (10) :4386-4396.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCε; PKCι
Frequently Asked Questions
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