BCL6 PROTAC 1
Product Specifications
UNSPSC Description
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research[1].
Target Antigen
BCL6; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl6-protac-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1)C(N2C(C(C(OCCOCCOCCCNC(CCC(N3CCN(C4=NC=C(Cl)C(N5)=N4)[C@@H](COCCOC6=CC5=CC(CC7)=C6N(C)C7=O)C3)=O)=O)=CC=C8)=C8C2=O)=O)CCC1=O
Molecular Weight
946.40
References & Citations
[1]McCoull W, et al. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122829/BCL6-PROTAC-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122829/
Clinical Information
No Development Reported
CAS Number
2257479-54-0
Curated Selection
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