Tyrosylleucine

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

Product Specifications

CAS Number

[17355-10-1]

Product Name Alternative

Tyr-Leu

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Peptides

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tyrosylleucine.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)

Smiles

CC(C[C@H](NC([C@@H](N)CC1=CC=C(C=C1)O)=O)C(O)=O)C

Molecular Formula

C15H22N2O4

Molecular Weight

294.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10 (1) :2257.|[2]Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584 (3) :599-604.