Quifenadine

Quifenadine (Compound 3a), the hydroxyl- (diphenyl) methyl quinuclidine derivative, is a M3 receptor antagonist with an IC50 value > 1000 nM. Quifenadine can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[10447-39-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/quifenadine.html

Solubility

10 mM in DMSO

Smiles

OC(C1CN2CCC1CC2)(C3=CC=CC=C3)C4=CC=CC=C4

Molecular Formula

C20H23NO

Molecular Weight

293.40

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lainé DI, et al. Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem. 2009 Apr 23;52 (8) :2493-505.