Org 25935

Org 25935 is a potent and selective glycine transporter 1 protein (GlyT1) inhibitor with an IC50 value of 100 nM. Org 25935 can decrease ethanol (EtOH) intake and EtOH preference in rats, whereas water intake is unaffected. Org 25935 can be used for researching alcohol dependence or abuse[1].

Product Specifications

CAS Number

[949588-40-3]

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/org-25935.html

Solubility

10 mM in DMSO

Smiles

OC(CN(C)C[C@@H]1[C@H](C2=CC=CC=C2)C3=CC=C(OC)C=C3CC1)=O.Cl

Molecular Formula

C21H26ClNO3

Molecular Weight

375.89

References & Citations

[1]Molander A, et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol. 2007;42 (1) :11-18.