CSRM617
Product Specifications
UNSPSC Description
CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model[1]
Target Antigen
Androgen Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csrm617.html
Solubility
10 mM in DMSO
Smiles
O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O
Molecular Weight
255.23
References & Citations
[1]Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122611/CSRM617-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122611/
Clinical Information
No Development Reported
CAS Number
787504-88-5
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