VU0134992
VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].
Product Specifications
CAS Number
[755002-90-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vu0134992.html
Purity
99.30
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br
Molecular Formula
C20H31BrN2O2
Molecular Weight
411.38
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Glia. 2021 Oct;69 (10) :2474-2487.|Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869 (5) :166700.|Nat Commun. 2022 Nov 21;13 (1) :7136.
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