Mensacarcin
Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1][2].
Product Specifications
CAS Number
808750-39-2
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Payload; Antibiotic; Apoptosis; Mitochondrial Metabolism
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mensacarcin.html
Solubility
10 mM in DMSO
Smiles
CO[C@@H]1[C@@]23[C@](C(C4=CC=CC(OC)=C14)=O)([C@@H]([C@H](C)[C@](C([C@H]5[C@H](C)O5)=O)(O)[C@@H]3O)O)O2
Molecular Formula
C21H24O9
Molecular Weight
420.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Frequently Asked Questions
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