Mensacarcin

Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1][2].

Product Specifications

CAS Number

[808750-39-2]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Payload; Antibiotic; Apoptosis; Mitochondrial Metabolism

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mensacarcin.html

Solubility

10 mM in DMSO

Smiles

CO[C@@H]1[C@@]23[C@](C(C4=CC=CC(OC)=C14)=O)([C@@H]([C@H](C)[C@](C([C@H]5[C@H](C)O5)=O)(O)[C@@H]3O)O)O2

Molecular Formula

C21H24O9

Molecular Weight

420.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Birte Plitzko, et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells. J Biol Chem. 2017 Dec 22;292 (51) :21102-21116.|[2]Lutz F. Tietze, et al. Intramolecular Heck Reactions for the Synthesis of the Novel Antibiotic Mensacarcin: Investigation of Catalytic, Electronic and Conjugative Effects in the Preparation of the Hexahydroanthracene Core. Chemistry Europe. Volume2005, Issue9.