Sabiporide (hydrochloride)

Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM) . Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].

Product Specifications

CAS Number

[324758-66-9]

Product Name Alternative

BIIB 722 (hydrochloride)

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sabiporide-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CN3)=O)CC2)C(C(F)(F)F)=C1.[H]Cl

Molecular Formula

C18H20ClF3N6O2

Molecular Weight

444.84

References & Citations

[1]Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459 (2-3) :151-8.|[2]Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061 (1) :67-71.