8-Deazafolic acid

8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691) . 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice[1].

Product Specifications

CAS Number

[51989-25-4]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-deazafolic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(CC[C@H](NC(C1=CC=C(C=C1)NCC2=CC=C(NC(N)=NC3=O)C3=N2)=O)C(O)=O)O

Molecular Formula

C20H20N6O6

Molecular Weight

440.41

References & Citations

[1]Carroll Temple Jr, et al. New synthesis of N-[4-[[ (2-amino-4 (3H) -oxopyrido[3,2-d]pyrimidin-6-yl) methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J. Med. Chem. 1981, 24, 10, 1254–1258.