Lovastatin acid
Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1].
Product Specifications
CAS Number
[75225-51-3]
Product Name Alternative
Mevinolinic acid; MSD803
UNSPSC
12352211
Hazard Statement
H351-H361-H413
Target
Drug Metabolite; HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lovastatin-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O
Molecular Formula
C24H38O6
Molecular Weight
422.55
Precautions
P273-P280-P405-P501
References & Citations
[1]Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77 (7) :3957-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Curated Selection
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