Thiolactomycin
Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].
Product Specifications
CAS Number
82079-32-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thiolactomycin.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
C=C/C(C)=C/[C@@]1(C(O)=C(C(S1)=O)C)C
Molecular Formula
C11H14O2S
Molecular Weight
210.29
Precautions
H302, H315, H319
References & Citations
[1]Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276 (9) :6551-9.|[2]Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40 (12) :2813-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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