Thiolactomycin

Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].

Product Specifications

CAS Number

[82079-32-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thiolactomycin.html

Purity

97.0

Solubility

10 mM in DMSO

Smiles

C=C/C(C)=C/[C@@]1(C(O)=C(C(S1)=O)C)C

Molecular Formula

C11H14O2S

Molecular Weight

210.29

Precautions

H302, H315, H319

References & Citations

[1]Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276 (9) :6551-9.|[2]Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40 (12) :2813-9.