SKF 38393 (hydrobromide)
SKF 38393 ((±) -SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].
Product Specifications
Product Name Alternative
(±) -SKF-38393 (hydrobromide)
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf-38393-hydrobromide.html
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Br
Molecular Formula
C16H18BrNO2
Molecular Weight
336.22
References & Citations
[1]Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7 (1) :213-222.|[2]Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84 (1) :257-64.|[3]Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892 (2) :241-7.|[4]Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94 (4) :1063-70.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12237/SKF-38393-hydrobromide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12237/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
Citation 01
Cell Rep. 2025 Mar 1;44 (3) :115364.|Free Radic Biol Med. 2023 Jun:202:2-16.|Acta Pharmacol Sin. 2025 May 6.|Adv Sci (Weinh) . 2025 Aug 23:e03409.|Aquaculture. 2025 Apr 15.|Behav Brain Res. 2022 Mar 26:422:113759.|Biomedicines. 2024 May 9;12 (5) :1046.|bioRxiv. 2019 Oct.|bioRxiv. 2020 Jun.|EMBO Rep. 2022 Feb 3;23 (3) :e53191.|Eur J Pharmacol. 2024 Jul 30:176866.|Insect Biochem Mol Biol. 2025 May:180:104312.|J Affect Disord. 2024 Jul 1:356:586-596.|Med Sci Monit. 2021 Oct 18;27:e933278.|Microbiome. 2020 Aug 20;8 (1) :120.|Nat Commun. 2024 May 1;15 (1) :3685.|Neurobiol Aging. 2021 Jun:102:1-16.|Neuron. 2024 Apr 3;112 (7) :1150-1164.e6.
CAS Number
[20012-10-6]
Available Sizes
Curated Selection
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