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SKF 38393 (hydrobromide)

SKF 38393 ((±) -SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

Product Specifications

CAS Number

20012-10-6

Product Name Alternative

(±) -SKF-38393 (hydrobromide)

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/skf-38393-hydrobromide.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Br

Molecular Formula

C16H18BrNO2

Molecular Weight

336.22

References & Citations

[1]Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7 (1) :213-222.|[2]Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84 (1) :257-64.|[3]Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892 (2) :241-7.|[4]Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94 (4) :1063-70.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D1 Receptor

Citation 01

Cell Rep. 2025 Mar 1;44 (3) :115364.|Free Radic Biol Med. 2023 Jun:202:2-16.|Acta Pharmacol Sin. 2025 May 6.|Adv Sci (Weinh) . 2025 Aug 23:e03409.|Aquaculture. 2025 Apr 15.|Behav Brain Res. 2022 Mar 26:422:113759.|Biomedicines. 2024 May 9;12 (5) :1046.|bioRxiv. 2019 Oct.|bioRxiv. 2020 Jun.|EMBO Rep. 2022 Feb 3;23 (3) :e53191.|Eur J Pharmacol. 2024 Jul 30:176866.|Insect Biochem Mol Biol. 2025 May:180:104312.|J Affect Disord. 2024 Jul 1:356:586-596.|Med Sci Monit. 2021 Oct 18;27:e933278.|Microbiome. 2020 Aug 20;8 (1) :120.|Nat Commun. 2024 May 1;15 (1) :3685.|Neurobiol Aging. 2021 Jun:102:1-16.|Neuron. 2024 Apr 3;112 (7) :1150-1164.e6.

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