Thrazarine

Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research[1].

Product Specifications

CAS Number

120128-14-5

Product Name Alternative

FR 900840

UNSPSC

12352211

Target

Antibiotic

Type

Natural Products

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thrazarine.html

Solubility

10 mM in DMSO

Smiles

N[C@H](C(O)=O)COC(C([C@@H](C)O)=[N+]=[N-])=O

Molecular Formula

C7H11N3O5

Molecular Weight

217.18

References & Citations

[1]Kameyama T, et al. Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo) . 1988 Nov;41 (11) :1561-7.