Ansatrienin B

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

Product Specifications

CAS Number

[82189-04-6]

Product Name Alternative

Mycotrienin II

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ansatrienin-b.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(C1CCCCC1)N[C@@H](C(O[C@@H](C/C=C/C=C/C=C/[C@@H](C2)OC)[C@@H]([C@H](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C

Molecular Formula

C36H50N2O8

Molecular Weight

638.79

References & Citations

[1]M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo) . 1982 Nov;35 (11) :1460-6.|[2]D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270 (43) :25949-55.|[3]Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo) . 2011 May;64 (5) :361-6.