Ansatrienin B
Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].
Product Specifications
CAS Number
82189-04-6
Product Name Alternative
Mycotrienin II
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ansatrienin-b.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(C1CCCCC1)N[C@@H](C(O[C@@H](C/C=C/C=C/C=C/[C@@H](C2)OC)[C@@H]([C@H](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C
Molecular Formula
C36H50N2O8
Molecular Weight
638.79
References & Citations
[1]M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo) . 1982 Nov;35 (11) :1460-6.|[2]D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270 (43) :25949-55.|[3]Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo) . 2011 May;64 (5) :361-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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