Obeticholic acid-d4-1

Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

Product Specifications

Product Name Alternative

INT-747-d4; 6-ECDCA-d4-1; 6-Ethylchenodeoxycholic acid-d4-1

UNSPSC

12352211

Target

Autophagy; FXR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Others

Purity

99.84

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL|Ethanol : ≥ 50mg/mL

Smiles

C[C@@]([C@]1([H])[C@@H](C)[C@H]2O)(CC([2H])([2H])[C@@H](O)C1([2H])[2H])[C@]3([H])[C@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(O)=O)([H])[C@]4(C)CC3

Molecular Formula

C25H38D4O4

Molecular Weight

410.62

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pellicciari R, et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem. 2002 Aug 15;45 (17) :3569-72.|[3]Ghebremariam YT, et al. FXR agonist INT-747 upregulates DDAH expression and enhances sensitivity in high-salt fed Dahl rats. PLoS One. 2013 Apr 4;8 (4) :e60653.|[4]Verbeke L, et al. The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats. Am J Pathol. 2015 Feb;185 (2) :409-19.|[5]Fiorucci S, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther. 2005 May;313 (2) :604-12.