L-869298
Product Specifications
UNSPSC Description
L-869298 is a potent and selective PDE4 inhibitor with an IC50 of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-869298.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)(C1=NC=C(S1)[C@@H](CC2=C[N+]([O-])=CC=C2)C3=CC=C(C(OC4CC4)=C3)OC(F)F)C(F)(F)F
Molecular Weight
570.45
References & Citations
[1]Richard W Friesen, et al. Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. J Med Chem. 2003 Jun 5;46(12):2413-26.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122167/L-869298-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122167/
Clinical Information
No Development Reported
CAS Number
362718-73-8
Curated Selection
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