JNJ-10311795
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].
Product Specifications
CAS Number
[518062-14-1]
Product Name Alternative
RWJ-355871
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-10311795.html
Purity
98.66
Solubility
10 mM in DMSO
Smiles
OP(O)(C(C1=C2C=CC=CC2=CC=C1)C(C3=C(C(N(C)C4CCN(C(C5=CC=C6C=CC=CC6=C5)=O)CC4)=O)C=C7C=CC=CC7=C3)=O)=O
Molecular Formula
C40H35N2O6P
Molecular Weight
670.69
References & Citations
[1]Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280 (18) :18001-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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