Spiclomazine (hydrochloride)

Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis[1][2].

Product Specifications

CAS Number

[27007-85-8]

Product Name Alternative

APY-606; Clospirazine (hydrochloride)

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spiclomazine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1CSC2(N1)CCN(CC2)CCCN3C4=C(SC5=CC=C(C=C35)Cl)C=CC=C4.[H]Cl

Molecular Formula

C22H25Cl2N3OS2

Molecular Weight

482.49

References & Citations

[1]Zhao W, et al. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8 (6) :e66362.|[2]Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9 (6) :6938-6951.