ACG548B

ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase) . ACG548B can be uesd for the study of myasthenia gravis and neuromuscular blockade[1].

Product Specifications

CAS Number

[795316-16-4]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acg548b.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C=C4)=C3)=CC=C2)C=C1)C6=CC=C(Cl)C=C6.[Br-].[Br-]

Molecular Formula

C38H34Br2Cl2N4

Molecular Weight

777.42

References & Citations

[1]Conejo-García A, et al. Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity. J Med Chem. 2011;54 (8) :2627-2645.