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(S) -BI-1001

(S) -BI-1001 (Compound 11) is an active S-enantiomer of BI-1001. (S) -BI-1001 exhibits antiviral potency against HIV-1 integrase with an IC50 of 28 nM, an EC50 of 450 nM and a Kd of 4.7 μM[1].

Product Specifications

CAS Number

957889-73-5

UNSPSC

12352005

Target

HIV Integrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/s-bi-1001.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=C(C=C(Br)C=C3)C3=NC(C)=C2[C@H](OC)C(O)=O)C=C1

Molecular Formula

C19H15BrClNO3

Molecular Weight

420.68

References & Citations

[1]Fader LD, et al. Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. ACS Med Chem Lett. 2014 Jan 22;5 (4) :422-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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